GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13393800 | 1 | rs1201451 | chr2:233419396 | EIF4E2 | chr2:233415357-233448349:+ | 0.19 | 4.34 | 1.53E-5 | Height |
| BRCA | cis | rs4118325 | 1 | rs12021578 | chr1:107597501 | NTNG1 | chr1:107682629-108024471:+ | 0.16 | 3.56 | 0.000389 | AIDS |
| BRCA | cis | rs4118325 | 1 | rs12021578 | chr1:107597501 | PRMT6 | chr1:107599267-107601907:+ | 0.22 | 4.45 | 9.3E-6 | AIDS |
| BRCA | cis | rs2275426 | 1 | rs12021587 | chr1:46472759 | CCDC163P | chr1:45960581-45965646:- | -0.39 | -11.7 | 7.61E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12021587 | chr1:46472759 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.53 | 0.000435 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12021587 | chr1:46472759 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.07 | 4.6E-7 | Body mass index |
| BRCA | cis | rs6684514 | 1 | rs12022194 | chr1:156312331 | BGLAP | chr1:156182784-156213112:+ | 0.18 | 4.85 | 1.4E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12022194 | chr1:156312331 | CCT3 | chr1:156278752-156308195:- | -0.12 | -3.68 | 0.000245 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12023438 | chr1:156254358 | BGLAP | chr1:156182784-156213112:+ | 0.21 | 5.54 | 3.71E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12023438 | chr1:156254358 | C1orf85 | chr1:156259882-156265449:- | -0.11 | -3.52 | 0.000457 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12023704 | chr1:156294149 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.19 | 2.58E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12024813 | chr1:156224529 | BGLAP | chr1:156182784-156213112:+ | 0.18 | 4.66 | 3.63E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12024813 | chr1:156224529 | C1orf85 | chr1:156259882-156265449:- | -0.12 | -3.61 | 0.000319 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12027103 | chr1:156244856 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.36 | 1.02E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12027741 | chr1:156248148 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.36 | 1.02E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |